Beta-Agonist versus Botox A® Trial for Urgency Urinary Incontinence (BEST) Trial: Therapy for Urge Urinary Incontinence
The purpose of this study is to fill the evidence gap with direct-comparison data on patient-important efficacy and safety outcomes between an oral medication (Mirabegron or Vibegron) versus Botox A® in the treatment of Urgency Urinary Incontinence. 432 women across 5 sites in the United States will be asked to participate. Women will be followed for a 12-month period.
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TULIP: Training for Urinary Leakage Improvement after Pregnancy
TULIP is comparing three different pelvic muscle exercise strategies for improving urinary leakage after pregnancy:
- Patient Education: Detailed information and instructions about lifestyle changes and pelvic muscle exercises that may improve accidental bladder leakage.
- Pelvic Floor Muscle Therapy (PFMT): Coaching sessions with a skilled provider to learn and practice pelvic muscle exercises.
- Pelvic Muscle Exercises with Leva®: Exercises guided by an at-home motion-based vaginal insert device (Leva®) that connects wirelessly with a smartphone app to inform the user when correct exercises are being performed.
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BASIS: Transurethral Bulking Agent Injection versus Single- Incision Sling for Stress Urinary Incontinence
BASIS is comparing two treatments for people with SUI. Current evidence suggests that they may be less invasive with fewer side effects than full-length mid-urethral sling procedures. These treatments are commercially available and FDA approved for patients with SUI. Both procedures are routine for your condition and are not experimental.
- Transurethral Bulking Agent Injection (TBA): Injection of Bulkamid material into the urethra to lessen SUI by sealing the urethra tighter.
- Single-Incision Sling (SIS): Mesh sling placed through a small incision in the vagina which lessens SUI by supporting the urethra during physical straining.
